Methyl 5-(2-Fluoro-4-nitrophenyl)furan-2-carboxylate
نویسندگان
چکیده
5-Phenyl-furan-2-carboxylic acids have emerged as a new, promising class of antimycobacterial agents that the ability to interfere with iron homeostasis. Considering lack structural data on these compounds, we analyzed crystal fluorinated ester derivative 5-(4-nitrophenyl)furan-2-carboxylic acid, one most potent candidates in series. Here, describe preparation methyl 5-(2-fluoro-4-nitrophenyl)furan-2-carboxylate (1) and its analysis by 1H-NMR, 13C-NMR, HRMS, SC-XRD.
منابع مشابه
Ethyl 5-(4-Bromophenyl)-4-methyl-1H-pyrrole- 2-carboxylate
This note describes a sequence converting an oxime-substituted pyrrolidine into a trisubstituted pyrrole structure. The synthetic route is based on a double chlorination of the pyrrolidine substrate followed by the base induced formation of both an imine and a nitrile oxide functionality. The latter reacts with an immobilized thiourea to yield an isothiocyanate which upon elimination generates ...
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ژورنال
عنوان ژورنال: Molbank
سال: 2022
ISSN: ['1422-8599']
DOI: https://doi.org/10.3390/m1492